The article analyzes the impact of geopolitical events that unfolded against the background of the introduction of numerous sanctions against the Russian Federation on Russian-African relations and the prospects for their development. The authors proceed from the fact that the weight and role of the African continent in world politics and economy is increasing. And, despite the pressure from Western countries, primarily the United States, African countries are demonstrating their interest in expanding cooperation with Russia. And in this regard, sufficiently effective efforts are required to expand the Russian-African partnership, in particular in those areas where Russia has competitive advantages, production capacities, experience and high competencies. These include nuclear and hydro- power, exploration and development of natural resources, military-technical cooperation, education, healthcare, including the fight against epidemics. In turn, Africa has more and more opportunities to reduce its critical dependence on the West and puts more and more emphasis on the countries of the South. Russia is undoubtedly interested in the African states as a country with high weight in the international arena, owning a large military-technical arsenal, upholding the concept of a multipolar world and considering Africa as a promising and effective partner.